Pharmacologic Augmentation of Hypoxia-Inducible Factor–1 with Mimosine Boosts the Bactericidal Capacity of Phagocytes
نویسندگان
چکیده
Hypoxia-inducible factor (HIF)–1 is activated on exposure to bacterial pathogens and regulates the innate immune functions of phagocytes. We show here that the HIF-1 agonist mimosine can boost the capacity of human phagocytes and whole blood to kill the leading pathogen Staphylococcus aureus in a dose-dependent fashion and reduce the lesion size in a murine model of S. aureus skin infection. This provides the first proof of principle for a novel approach to the treatment of bacterial infection by pharmacologically augmenting the host phagocytic cell function.
منابع مشابه
Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes.
Hypoxia-inducible factor (HIF)-1alpha is activated on exposure to bacterial pathogens and regulates the innate immune functions of phagocytes. We show here that the HIF-1alpha agonist mimosine can boost the capacity of human phagocytes and whole blood to kill the leading pathogen Staphylococcus aureus in a dose-dependent fashion and reduce the lesion size in a murine model of S. aureus skin inf...
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